• Problem. Given current infrastructure at GNF, in-house service development was beneficial over outsourcing in terms of fast turn-around time and intellectual property protection.
• Action. Developed a high-confidence antibody V-region reconstruction method utilized public genomics database of antibodies, classified most probable template sequence, reconstructed full information from fragmented data.
• Result. Provided accurate full de novo sequence for antibody biotherapeutics. Now fully functional in-house service at no risk of confidential information disclosure by leveraging combined information protocol (genomics/proteomics/informatics).
• Computing.Python, R (ggplot2), Database Retrieval
• Conference Talk. Park, I.-H. & Brock, A. “Genomics/Proteomics/Informatics Complementary Approach to High Confident Reconstruction of Antibody Vregion Sequence” ACS West Coast Analytical Chemistry Symposium, Apr 2015

Presentation